• lynx
this-is-wild:

Sleeping family of lynx(Roberto Carnevali)

    lynx

    this-is-wild:

    Sleeping family of lynx()

    Apr
    14
    2014
  • blackpaint20:

BPIX ©
Submitted by blastpics

    blackpaint20:

    BPIX ©

    Submitted by 

    Apr
    13
    2014
  • thescienceofreality:

Engineered vaginas grown in women for the first time by Catherine de Lange | Image Credit: Cliparea/Shutterstock via Science Alert.

Vaginas grown in a lab from the recipients’ own cells have been successfully transferred to the body for the first time.
The surgery was carried out on four women who were born without vaginal canals because of a rare condition. The women, who were teenagers at the time of the operation, now have fully functioning sexual organs.
"After the operation they were able to function normally. They had normal levels of desire, arousal, satisfaction and orgasm," says Anthony Atala at Wake Forest School of Medicine in North Carolina, who led the research. He published the results only after four to eight years had elapsed following surgery, enough time for him to be sure there were no long-term complications.
The four women had undeveloped vaginas because they all have a severe form of a condition called Mayer-Rokitansky-Küster-Hauser Syndrome (MKRH), which affects about 1 in 5000 women. They also had some abnormal development of the uterus, although they did have a vulva – the external part of the sex organ which includes the labia and the clitoris. They were not able to have penetrative sex or menstruate. One of the women was diagnosed after her menstrual blood had collected in her abdomen.
As well as having physical implications, a diagnosis of MKRH is also a huge psychological burden for women.

Maturity challenge
Building on techniques the group developed in the 1990s and perfected on rabbits, Atala and his colleagues removed a small part of the vulva from each woman and grew the cells in the lab. After about four weeks they had enough cells to begin to lay them on to a degradable scaffold one layer at a time “like the layers of a cake”, he says.
The challenge was how to get the cells to grow to the right level of maturity in the lab, says Atala. You need to make sure that the cells are mature enough so that when you implant them into the body, they can recruit other cells in the body to form tissue that includes nerves and blood vessels.
Working with surgeons at the Federico Gomez Children’s Hospital of Mexico in Mexico City, Atala’s team used MRI scans to calculate the appropriate shape and size of the scaffolds for each patient. After cells had established themselves on these scaffolds, surgeons created a cavity in the abdomen and inserted the engineered vagina. It was then stitched in place, connected at the top to the uterus.
The women used a stent for six weeks to make sure the structure maintained the right shape.
The scaffold was made of a collagen matrix and degraded spontaneously over the months following surgery. In that time, the implanted cells matured into the normal tissue of the vaginal wall, including the right layers of muscle and epithelial cells (see video). The vagina was fully developed after six months, and the women were able to menstruate and have sex.
Better than a skin graft
Atala hopes that in the future, the technique could be used to treat not only women who have congenital vaginal defects but also those who have suffered damage through trauma – for instance, because of a car accident or cancer.
Currently it is possible to surgically create vaginas using grafts from either intestinal or skin tissue, but these can lead to severe complications. Skin cell grafts do not provide lubrication which causes pain during sex, and can thicken to the point where the vagina closes. Intestinal cells secrete mucus constantly, which is unhygienic and causes an unpleasant odour. Using the women’s own cells from the vulva gets around these issues.
Knowing that the engineered tissue originates from the recipient’s own body can be reassuring for them, says Sylvie Miot at the University of Basel, Switzerland, whose team has also successfully engineered new nostrils for patients who had to have skin cancers removed from their nose. Their findings are being published in the same issue of the Lancet.
Both studies involved small numbers of patients, but they provide the first strong evidence that nerve and blood vessels can reconnect to large patches of bioengineered tissues directly inside the body.
Normal life
The findings also show that lab-engineered organs can grow to maturity healthily inside the body, says Martin Birchall at University College London. The women were aged between 13 and 18 years old when the surgery took place so their bodies were still developing. Birchall, who pioneered the first transplant of a human windpipe using the recipient’s stem cells, calls the results “very meaningful”.
One of the recipients, who wished to remain anonymous, said the treatment opened up new possibilities. “I truly feel fortunate, because I’ll have a normal life – completely normal,” she says. “It’s important to let other girls that have the same problem know that it does not end knowing that you have the disease, because there is a treatment.”
Two of the four women have a functional uterus, so the big question is whether they will be able to have children. “They haven’t tried,” says Atala, “but they can ovulate, so there is no reason to suspect that they cannot.”
Journal references: The Lancet, DOI: 10.1016/S0140-6736(14)60542-0 and 10.1016/S01460544-4

    thescienceofreality:

    Engineered vaginas grown in women for the first time by Catherine de Lange | Image Credit: Cliparea/Shutterstock via Science Alert.

    Vaginas grown in a lab from the recipients’ own cells have been successfully transferred to the body for the first time.

    The surgery was carried out on four women who were born without vaginal canals because of a rare condition. The women, who were teenagers at the time of the operation, now have fully functioning sexual organs.

    "After the operation they were able to function normally. They had normal levels of desire, arousal, satisfaction and orgasm," says Anthony Atala at Wake Forest School of Medicine in North Carolina, who led the research. He published the results only after four to eight years had elapsed following surgery, enough time for him to be sure there were no long-term complications.

    The four women had undeveloped vaginas because they all have a severe form of a condition called Mayer-Rokitansky-Küster-Hauser Syndrome (MKRH), which affects about 1 in 5000 women. They also had some abnormal development of the uterus, although they did have a vulva – the external part of the sex organ which includes the labia and the clitoris. They were not able to have penetrative sex or menstruate. One of the women was diagnosed after her menstrual blood had collected in her abdomen.

    As well as having physical implications, a diagnosis of MKRH is also a huge psychological burden for women.

    Maturity challenge

    Building on techniques the group developed in the 1990s and perfected on rabbits, Atala and his colleagues removed a small part of the vulva from each woman and grew the cells in the lab. After about four weeks they had enough cells to begin to lay them on to a degradable scaffold one layer at a time “like the layers of a cake”, he says.

    The challenge was how to get the cells to grow to the right level of maturity in the lab, says Atala. You need to make sure that the cells are mature enough so that when you implant them into the body, they can recruit other cells in the body to form tissue that includes nerves and blood vessels.

    Working with surgeons at the Federico Gomez Children’s Hospital of Mexico in Mexico City, Atala’s team used MRI scans to calculate the appropriate shape and size of the scaffolds for each patient. After cells had established themselves on these scaffolds, surgeons created a cavity in the abdomen and inserted the engineered vagina. It was then stitched in place, connected at the top to the uterus.

    The women used a stent for six weeks to make sure the structure maintained the right shape.

    The scaffold was made of a collagen matrix and degraded spontaneously over the months following surgery. In that time, the implanted cells matured into the normal tissue of the vaginal wall, including the right layers of muscle and epithelial cells (see video). The vagina was fully developed after six months, and the women were able to menstruate and have sex.

    Better than a skin graft

    Atala hopes that in the future, the technique could be used to treat not only women who have congenital vaginal defects but also those who have suffered damage through trauma – for instance, because of a car accident or cancer.

    Currently it is possible to surgically create vaginas using grafts from either intestinal or skin tissue, but these can lead to severe complications. Skin cell grafts do not provide lubrication which causes pain during sex, and can thicken to the point where the vagina closes. Intestinal cells secrete mucus constantly, which is unhygienic and causes an unpleasant odour. Using the women’s own cells from the vulva gets around these issues.

    Knowing that the engineered tissue originates from the recipient’s own body can be reassuring for them, says Sylvie Miot at the University of Basel, Switzerland, whose team has also successfully engineered new nostrils for patients who had to have skin cancers removed from their nose. Their findings are being published in the same issue of the Lancet.

    Both studies involved small numbers of patients, but they provide the first strong evidence that nerve and blood vessels can reconnect to large patches of bioengineered tissues directly inside the body.

    Normal life

    The findings also show that lab-engineered organs can grow to maturity healthily inside the body, says Martin Birchall at University College London. The women were aged between 13 and 18 years old when the surgery took place so their bodies were still developing. Birchall, who pioneered the first transplant of a human windpipe using the recipient’s stem cells, calls the results “very meaningful”.

    One of the recipients, who wished to remain anonymous, said the treatment opened up new possibilities. “I truly feel fortunate, because I’ll have a normal life – completely normal,” she says. “It’s important to let other girls that have the same problem know that it does not end knowing that you have the disease, because there is a treatment.”

    Two of the four women have a functional uterus, so the big question is whether they will be able to have children. “They haven’t tried,” says Atala, “but they can ovulate, so there is no reason to suspect that they cannot.”

    Journal references: The Lancet, DOI: 10.1016/S0140-6736(14)60542-0 and 10.1016/S01460544-4

    Apr
    13
    2014
  • Pan and Syrinx  ~ Adrien BDJ
via

    Pan and Syrinx  ~ Adrien BDJ

    via

    Apr
    12
    2014
  • Michelangelo’s revenge
blackpaint20:

Michelangelo’s revenge

    Michelangelo’s revenge

    blackpaint20:

    Michelangelo’s revenge

    Apr
    12
    2014
  • spectacularuniverse:

Meet the pollen-gilded bat (Phyllonycteris poeyi), really living up to its name. This species, from eastern Cuba, has specialised fur that grips onto pollen, creating a very handy moveable feast.Read more

    spectacularuniverse:

    Meet the pollen-gilded bat (Phyllonycteris poeyi), really living up to its name. This species, from eastern Cuba, has specialised fur that grips onto pollen, creating a very handy moveable feast.

    Read more


    Apr
    12
    2014
  • Happy SatyrDay! 
PAN AND SYRINX
Carlo Alberto Palumbo

    Happy SatyrDay! 

    PAN AND SYRINX

    Carlo Alberto Palumbo

    Apr
    12
    2014
  • soldier on

    soldier on

    (Source: mummyqueerest)

    Apr
    11
    2014
  • Apr
    10
    2014

  • Incredible Living Sculptures– Robert Cannon

    asylum-art:

    Incredible Living Sculptures– Robert Cannon

    These are fascinating sculptures done by Robert Cannon . He calls the work Terraform Sculpture. TERRAFORM (literally, “Earth-shaping”) the process of deliberate modification of the atmosphere, temperature, surface topography or ecology to be similar to those of Earth to make it habitable by humans. While in Robert’s case, he uses concrete and mosses with most of his creations.

    Apr
    10
    2014
  • Hercules at the Feet of Omphale[1] by Gustave Boulanger
jahsonic:

Hercules at the Feet of Omphale[1] by Gustave Boulanger

“Hercules and Omphale,” from a painting by Boulanger. Masculine virility regresses to effeminacy and homosexuality after slaying a friend. Hercules wore Omphale’s clothing for three years while she dominated him and wore his lion’s skin; the effect of shame and sorrow upon virility. —Sex and Sex Worship, Otto Augustus Wall (1846-1922)

    Hercules at the Feet of Omphale[1] by Gustave Boulanger

    jahsonic:

    Hercules at the Feet of Omphale[1] by Gustave Boulanger

    Hercules and Omphale,” from a painting by Boulanger. Masculine virility regresses to effeminacy and homosexuality after slaying a friend. Hercules wore Omphale’s clothing for three years while she dominated him and wore his lion’s skin; the effect of shame and sorrow upon virility. —Sex and Sex Worship, Otto Augustus Wall (1846-1922)

    Apr
    08
    2014
  • Elihu Vedder, The Fates Gathering in the Stars, 1887

    Elihu Vedder, The Fates Gathering in the Stars, 1887

    Apr
    08
    2014
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Flying Cat

Vintage Erotica and other things that strike my fancy.
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